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Article

Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.

The Journal of clinical investigation - 1 Mar 2007

Meyer-Lindenberg Andreas, Straub Richard E, Lipska Barbara K, Verchinski Beth A, Goldberg Terry, Callicott Joseph H, Egan Michael F, Huffaker Stephen S, Mattay Venkata S, Kolachana Bhaskar, Kleinman Joel E, Weinberger Daniel R

Abstract excerpt

Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs of abuse, and affecting striatal function and plasticity. Despite extensive preclinical work, there are almost no data on DARPP-32 function in humans. Here, we identify, through...

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Identifiers

PMID: 17290303
DOI: 10.1172/JCI30413
PMCID: PMC1784004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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