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Article

DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory.

PloS one - 1 Jan 2014

Di Giorgio Annabella, Smith Ryan M, Fazio Leonardo, D'Ambrosio Enrico, Gelao Barbara, Tomasicchio Aldo, Selvaggi Pierluigi, Taurisano Paolo, Quarto Tiziana, Masellis Rita, Rampino Antonio, Caforio Grazia, Popolizio Teresa, Blasi Giuseppe, Sadee Wolfgang, Bertolino Alessandro

Abstract excerpt

BACKGROUND: Prefrontal behavior and activity in humans are heritable. Studies in animals demonstrate an interaction between dopamine D2 receptors and nicotinic acetylcholine receptors on prefrontal behavior but evidence in humans is weak. Therefore, we hypothesize that genetic variation regulating dopamine D2 and nicotinic acetylcholine receptor signaling impact prefrontal cortex activity and related cognition....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24819610
DOI: 10.1371/journal.pone.0095997
PMCID: PMC4018353

Genes

DRD2
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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