Article
Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2015
Blasi Giuseppe, Selvaggi Pierluigi, Fazio Leonardo, Antonucci Linda Antonella, Taurisano Paolo, Masellis Rita, Romano Raffaella, Mancini Marina, Zhang Fengyu, Caforio Grazia, Popolizio Teresa, Apud Jose, Weinberger Daniel R, Bertolino Alessandro
Abstract excerpt
Dopamine D2 and serotonin 5-HT2A receptors contribute to modulate prefrontal cortical physiology and response to treatment with antipsychotics in schizophrenia. Similarly, functional variation in the genes encoding these receptors is also associated with these phenotypes. In particular, the DRD2 rs1076560 T allele predicts a lower ratio of expression of D2 short/long isoforms, suboptimal working memory...
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