Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptomic context of DRD1 is associated with prefrontal activity and behavior during working memory.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018

Fazio Leonardo, Pergola Giulio, Papalino Marco, Di Carlo Pasquale, Monda Anna, Gelao Barbara, Amoroso Nicola, Tangaro Sabina, Rampino Antonio, Popolizio Teresa, Bertolino Alessandro, Blasi Giuseppe

Abstract excerpt

Dopamine D1 receptor (D1R) signaling shapes prefrontal cortex (PFC) activity during working memory (WM). Previous reports found higher WM performance associated with alleles linked to greater expression of the gene coding for D1Rs (DRD1). However, there is no evidence on the relationship between genetic modulation of DRD1 expression in PFC and patterns of prefrontal activity during WM. Furthermore, previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Healthy Volunteers
Share to Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Memory

Share to Neuropsychological Tests

Share to Polymorphism, Single Nucleotide

Share to Prefrontal Cortex

Share to Receptors, Dopamine D1

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 29735686
DOI: 10.1073/pnas.1717135115
PMCID: PMC6003490

Genes

DRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic context of DRD1 is associated with prefrontal activity and behavior during working memory.PMID 29735686Read ↗

DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia.Semantic proximity Read ↗

Genetic Variation of a DRD2 Co-expression Network is Associated with Changes in Prefrontal Function After D2 Receptors Stimulation.Semantic proximity Read ↗

Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia.Semantic proximity Read ↗

Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance.Semantic proximity Read ↗

Distinct genetic signatures of cortical and subcortical regions associated with human memorySemantic proximity Read ↗

DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory.Semantic proximity Read ↗

Dysbindin-1 genotype effects on emotional working memory.Semantic proximity Read ↗

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.Semantic proximity Read ↗

Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.Semantic proximity Read ↗

Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans.Semantic proximity Read ↗

Association of functional genetic variation in PP2A with prefrontal working memory processing.Semantic proximity Read ↗

Neuropredictome: a data-driven predictome for cognitive, psychiatric, medical, and lifestyle factors on the brainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.