Article
DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine.
Psychopharmacology - 1 Jun 2014
Gelao Barbara, Fazio Leonardo, Selvaggi Pierluigi, Di Giorgio Annabella, Taurisano Paolo, Quarto Tiziana, Romano Raffaella, Porcelli Annamaria, Mancini Marina, Masellis Rita, Ursini Gianluca, De Simeis Giuseppe, Caforio Grazia, Ferranti Laura, Lo Bianco Luciana, Rampino Antonio, Todarello Orlando, Popolizio Teresa, Blasi Giuseppe, Bertolino Alessandro
Abstract excerpt
RATIONALE: Pharmacological stimulation of D2 receptors modulates prefrontal neural activity associated with working memory (WM) processing. The T allele of a functional single-nucleotide polymorphism (SNP) within DRD2 (rs1076560 G > T) predicts reduced relative expression of the D2S receptor isoform and less efficient neural cortical responses during WM tasks. OBJECTIVE: We used functional MRI to test the...
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