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Article

Polygenic risk for depression and the neural correlates of working memory in healthy subjects.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Oct 2017

Yüksel Dilara, Dietsche Bruno, Forstner Andreas J, Witt Stephanie H, Maier Robert, Rietschel Marcella, Konrad Carsten, Nöthen Markus M, Dannlowski Udo, Baune Bernhard T, Kircher Tilo, Krug Axel

Abstract excerpt

INTRODUCTION: Major depressive disorder (MDD) patients show impairments of cognitive functioning such as working memory (WM), and furthermore alterations during WM-fMRI tasks especially in frontal and parietal brain regions. The calculation of a polygenic risk score (PRS) can be used to describe the genetic influence on MDD, hence imaging genetic studies aspire to combine both genetics and neuroimaging data to...

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PMID: 28624581
DOI: 10.1016/j.pnpbp.2017.06.010

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