Article
Polygenic risk for schizophrenia associated with working memory-related prefrontal brain activation in patients with schizophrenia and healthy controls.
Schizophrenia bulletin - 1 May 2015
Kauppi Karolina, Westlye Lars T, Tesli Martin, Bettella Francesco, Brandt Christine L, Mattingsdal Morten, Ueland Torill, Espeseth Thomas, Agartz Ingrid, Melle Ingrid, Djurovic Srdjan, Andreassen Ole A
Abstract excerpt
Schizophrenia is a highly heritable and polygenic disease, and identified common genetic variants have shown weak individual effects. Many studies have reported altered working memory (WM)-related brain activation in schizophrenia, preferentially in the frontal lobe. Such differences in brain activations could reflect inherited alterations possibly involved in the disease etiology, or rather secondary...
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