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Article

Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment.

Brain : a journal of neurology - 1 May 2012

Tan Hao Yang, Chen Anthony G, Kolachana Bhaskar, Apud Jose A, Mattay Venkata S, Callicott Joseph H, Chen Qiang, Weinberger Daniel R

Abstract excerpt

Working memory is a limited capacity system that integrates and manipulates information across brief periods of time, engaging a network of prefrontal, parietal and subcortical brain regions. Genetic control of these heritable brain processes have been suggested by functional genetic variations influencing dopamine signalling, which affect prefrontal activity during complex working memory tasks. However, less is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22525159
DOI: 10.1093/brain/aws068
PMCID: PMC3338927

Genes

AKT1
DRD2
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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