Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.

doi:10.1371/journal.pone.0009348

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Article

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.

PloS one - 22 Feb 2010

Bertolino Alessandro, Taurisano Paolo, Pisciotta Nicola Marco, Blasi Giuseppe, Fazio Leonardo, Romano Raffaella, Gelao Barbara, Lo Bianco Luciana, Lozupone Madia, Di Giorgio Annabella, Caforio Grazia, Sambataro Fabio, Niccoli-Asabella Artor, Papp Audrey, Ursini Gianluca, Sinibaldi Lorenzo, Popolizio Teresa, Sadee Wolfgang, Rubini Giuseppe

Abstract excerpt

BACKGROUND: Variation of the gene coding for D2 receptors (DRD2) has been associated with risk for schizophrenia and with working memory deficits. A functional intronic SNP (rs1076560) predicts relative expression of the two D2 receptors isoforms, D2S (mainly pre-synaptic) and D2L (mainly post-sy...

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PMID: 20179754
DOI: 10.1371/journal.pone.0009348
PMCID: PMC2825256

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DRD2
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20179754-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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