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Article

Topoisomerase II regulates yeast genes with singular chromatin architectures.

Nucleic acids research - 1 Nov 2013

Nikolaou Christoforos, Bermúdez Ignacio, Manichanh Chaysavanh, García-Martinez José, Guigó Roderic, Pérez-Ortín José E, Roca Joaquim

Abstract excerpt

Eukaryotic topoisomerase II (topo II) is the essential decatenase of newly replicated chromosomes and the main relaxase of nucleosomal DNA. Apart from these general tasks, topo II participates in more specialized functions. In mammals, topo IIα interacts with specific RNA polymerases and chromatin-remodeling complexes, whereas topo IIβ regulates developmental genes in conjunction with chromatin remodeling and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23935120
DOI: 10.1093/nar/gkt707
PMCID: PMC3814376

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