Article

When TADs go bad: chromatin structure and nuclear organisation in human disease

2017-03-24

Abstract excerpt

Chromatin in the interphase nucleus is organised as a hierarchical series of structural domains, including self-interacting domains called topologically associating domains (TADs). This arrangement is thought to bring enhancers into closer physical proximity with their target genes, which often are located hundreds of kilobases away in linear genomic distance. TADs are demarcated by boundary regions bound by archi...

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Literature Corpus work: 855f094c-e546-510c-bc85-8f6c167c3d27
DOI: 10.12688/f1000research.10792.1

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