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Article

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.

Nature communications - 12 Mar 2015

Broderick Ronan, Nieminuszczy Jadwiga, Blackford Andrew N, Winczura Alicja, Niedzwiedz Wojciech

Abstract excerpt

During mitosis, sister chromatids must be faithfully segregated to ensure that daughter cells receive one copy of each chromosome. However, following replication they often remain entangled. Topoisomerase IIα (TOP2A) has been proposed to resolve such entanglements, but the mechanisms governing TOP2A recruitment to these structures remain poorly understood. Here, we identify TOPBP1 as a novel interactor of TOP2A,...

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Share to Anaphase
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Share to Centromere

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to DNA Topoisomerases, Type II

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Source

Open in PubMed Open full text

Identifiers

PMID: 25762097
DOI: 10.1038/ncomms7572
PMCID: PMC4374157

Genes

TOPBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.PMID 25762097Read ↗

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BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage ResponseSemantic proximity Read ↗

Chromosome length and perinuclear attachment constrain resolution of DNA intertwines.Semantic proximity Read ↗

Role of the Topoisomerase IIα Chromatin Tether domain in Nucleosome Binding & Chromosome SegregationSemantic proximity Read ↗

CIP2A coordinates phosphosignaling, mitosis, and the DNA damage responseSemantic proximity Read ↗

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.Semantic proximity Read ↗

Human topoisomerases and their roles in genome stability and organizationSemantic proximity Read ↗

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.Semantic proximity Read ↗

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Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation.Semantic proximity Read ↗

Mitotic tethering enables <i>en masse</i> inheritance of a shattered micronuclear chromosomeSemantic proximity Read ↗

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