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Article

Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2016

Ueda Takeshi, Nakata Yuichiro, Nagamachi Akiko, Yamasaki Norimasa, Kanai Akinori, Sera Yasuyuki, Sasaki Masato, Matsui Hirotaka, Honda Zen-Ichiro, Oda Hideaki, Wolff Linda, Inaba Toshiya, Honda Hiroaki

Abstract excerpt

Polycomb repressive complex 2 (PRC2) catalyzes the monomethylation, dimethylation, and trimethylation of histone H3 Lys27 (H3K27) and acts as a central epigenetic regulator that marks the repressive chromatin domain. Embryonic ectoderm development (EED), an essential component of PRC2, interacts with trimethylated H3K27 (H3K27me3) through the aromatic cage structure composed of its three aromatic amino acids,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27578866
DOI: 10.1073/pnas.1600070113
PMCID: PMC5027452

Genes

EED

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.PMID 27578866Read ↗

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