Article
Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains.
Molecular cell - 19 Mar 2026
Agius Samuel C, Boudes Marion, Healy Evan, Kim Yoona, Chang Yi-Cheng, Murray Melanie, Manent Jan, Rientjes Jeanette, Lai Zhihao, Nixon Sophie, Homman-Ludiye Jihane, Levina Vitalina, McGlinn Edwina, Davidovich Chen
Abstract excerpt
The Polycomb repressive complex 2 (PRC2) is essential for normal development by maintaining developmental gene repression. PRC2 deposits the repressive chromatin mark H3 lysine 27 tri-methyl (H3K27me3) through a read-write loop that involves direct interactions between PRC2 and H3K27me3. According to current models, the PRC2-H3K27me3 read-write loop is initiated by the PRC2 subunits JARID2 and PALI1 that mimic...
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