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Article

EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.

Development (Cambridge, England) - 18 Jul 2018

Zhang Le, Ettou Sandrine, Khalid Myda, Taglienti Mary, Jain Dhawal, Jung Youngsook L, Seager Catherine, Liu Yongqing, Ng Kar-Hui, Park Peter J, Kreidberg Jordan A

Abstract excerpt

Epigenetic regulation of gene expression has a crucial role allowing for the self-renewal and differentiation of stem and progenitor populations during organogenesis. The mammalian kidney maintains a population of self-renewing stem cells that differentiate to give rise to thousands of nephrons, which are the functional units that carry out filtration to maintain physiological homeostasis. The polycomb repressive...

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Share to Cell Differentiation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to LIM-Homeodomain Proteins

Share to Mice, Transgenic

Share to Nephrons

Share to Polycomb Repressive Complex 2

Share to Stem Cells

Source

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Identifiers

PMID: 29945864
DOI: 10.1242/dev.157149
PMCID: PMC6514390

Genes

EED

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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