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Article

PRC2-independent actions of H3.3K27M in embryonic stem cell differentiation.

Nucleic acids research - 28 Feb 2023

Cohen Lea R Z, Kaffe Binyamin, Deri Eden, Leibson Chen, Nissim-Rafinia Malka, Maman Moria, Harpaz Nofar, Ron Guy, Shema Efrat, Meshorer Eran

Abstract excerpt

The histone H3 variant, H3.3, is localized at specific regions in the genome, especially promoters and active enhancers, and has been shown to play important roles in development. A lysine to methionine substitution in position 27 (H3.3K27M) is a main cause of Diffuse Intrinsic Pontine Glioma (specifically Diffuse Midline Glioma, K27M-mutant), a lethal type of pediatric cancer. H3.3K27M has a dominant-negative...

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Identifiers

PMID: 36156096
DOI: 10.1093/nar/gkac800
PMCID: PMC9976889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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