Article
H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.
Nature genetics - 1 Jun 2026
Krug Brian, Hu Bo, Chen Haifen, Negrón-Lomas Claudia, Chen Xiao, El Mouatani Ahmed, Gretarsson Kristjan H, Ptack Adam, Deshmukh Shriya, Kabir Nisha, Jawhar Wajih, Andrade Augusto Faria, Jabbour Elias, Harutyunyan Ashot S, Wang Xinrui, Taylor Robert, Lee John J Y, Hulswit Maud, Faury Damien, Russo Caterina, Xu Xinjing, Yang Jiahan, Baguette Audrey, Dahl Nathan A, Weil Alexander G, Ellezam Benjamin, Dali Rola, Blanchette Mathieu, Wilson Khadija, Garcia Benjamin A, Soni Rajesh Kumar, Gallo Marco, Taylor Michael D, Kleinman Claudia L, Majewski Jacek, Jabado Nada, Lu Chao
Abstract excerpt
Polycomb repressive complex 2 (PRC2)-mediated histone H3 K27 trimethylation (H3K27me3) recruits canonical PRC1 (cPRC1) to maintain heterochromatin. In early development, Polycomb-regulated genes can display long-range three-dimensional interactions, many of which resolve during lineage differentiation. Here we report that Polycomb-anchored looping is controlled by H3K27me3 spreading and regulates target gene...
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