Article
Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation.
Nature communications - 17 Jun 2024
Nacev Benjamin A, Dabas Yakshi, Paul Matthew R, Pacheco Christian, Mitchener Michelle, Perez Yekaterina, Fang Yan, Soshnev Alexey A, Barrows Douglas, Carroll Thomas, Socci Nicholas D, St Jean Samantha C, Tiwari Sagarika, Gruss Michael J, Monette Sebastien, Tap William D, Garcia Benjamin A, Muir Tom, Allis C David
Abstract excerpt
Dysregulated epigenetic states are a hallmark of cancer and often arise from genetic alterations in epigenetic regulators. This includes missense mutations in histones, which, together with associated DNA, form nucleosome core particles. However, the oncogenic mechanisms of most histone mutations are unknown. Here, we demonstrate that cancer-associated histone mutations at arginines in the histone H3 N-terminal...
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