Article

H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2

2020-08-05

Abstract excerpt

Diffuse midline gliomas and posterior fossa type-A ependymomas contain the highly recurrent histone H3 K27M mutation and the H3 K27M-mimic EZHIP, respectively. In vitro , H3 K27M and EZHIP are competitive inhibitors of Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase activity. In vivo , these proteins reduce overall H3K27me3 levels, however residual peaks of H3K27me3 remain at CpG islands through an...

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Literature Corpus work: 9f8f3763-65fe-5c97-ad0a-fb6b2a1564cb
DOI: 10.1101/2020.08.05.236737

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