Article
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.
Molecular cell - 19 Nov 2020
Jain Siddhant U, Rashoff Andrew Q, Krabbenhoft Samuel D, Hoelper Dominik, Do Truman J, Gibson Tyler J, Lundgren Stefan M, Bondra Eliana R, Deshmukh Shriya, Harutyunyan Ashot S, Juretic Nikoleta, Jabado Nada, Harrison Melissa M, Lewis Peter W
Abstract excerpt
Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67), respectively. H3 K27M and EZHIP are competitive inhibitors of Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase activity. In vivo, these proteins reduce overall H3 lysine 27 trimethylation (H3K27me3) levels; however, residual peaks...
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