Article

Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin

2017-10-20

Abstract excerpt

<h4>SUMMARY</h4> PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials. Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product, H3K27me3, is specifically recognized and bound by an aromatic cage present in its EED subunit. The ensuing allosteric activation of the complex stimulates H3K27me3 deposition on chromatin. Here, we report a st...

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Literature Corpus work: d66846d7-3920-5f53-b7bb-44565de27688
DOI: 10.1101/206383

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