Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis

13 Apr 2017

Abstract excerpt

Abstract Polycomb repressive complex 2 (PRC2), a H3K27me3 methyltransferase complex, promotes the development of many organs by silencing ectopic transcription program. However, currently little is known about the role of PRC2 in blood and vascular development. In this study, we interrogated the function of embryonic ectoderm development (EED), a core PRC2 component, in both endothelial and hematopoietic tissues...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Prenatal Screening and Diagnostics
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28406475
DOI: 10.1038/cddis.2017.163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesisPMID 28406475Read ↗

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.Semantic proximity Read ↗

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.Semantic proximity Read ↗

EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.Semantic proximity Read ↗

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cellsSemantic proximity Read ↗

Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organizationSemantic proximity Read ↗

Early mammalian erythropoiesis requires the Dot1L methyltransferase.Semantic proximity Read ↗

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Semantic proximity Read ↗

MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1Semantic proximity Read ↗

Investigating the role of the human transcription factor VEZF1 in erythroid and vascular endothelial differentiationSemantic proximity Read ↗

Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.Semantic proximity Read ↗

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.Semantic proximity Read ↗

Vitamin C–dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.