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Article

Genomic context- and H2AK119 ubiquitination-dependent inheritance of human Polycomb silencing.

Science advances - 10 May 2024

Shafiq Tiasha A, Yu Juntao, Feng Wenzhi, Zhang Yizhe, Zhou Haining, Paulo Joao A, Gygi Steven P, Moazed Danesh

Abstract excerpt

Polycomb repressive complexes 1 and 2 (PRC1 and 2) are required for heritable repression of developmental genes. The cis- and trans-acting factors that contribute to epigenetic inheritance of mammalian Polycomb repression are not fully understood. Here, we show that, in human cells, ectopically induced Polycomb silencing at initially active developmental genes, but not near ubiquitously expressed housekeeping...

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Source

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Identifiers

PMID: 38718120
DOI: 10.1126/sciadv.adl4529
PMCID: PMC11078181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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