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Article

The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men.

European archives of psychiatry and clinical neuroscience - 1 Mar 2017

Sarubin Nina, Hilbert Sven, Naumann Felix, Zill Peter, Wimmer Anna-Maria, Nothdurfter Caroline, Rupprecht Rainer, Baghai Thomas C, Bühner Markus, Schüle Cornelius

Abstract excerpt

Genetic variations in the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) have been associated with maladaptive stress responses and major depressive disorder (MDD). In a case-control study design, we examined whether single nucleotide polymorphisms (SNPs) and haploid genotype (haplotype) associations of MR gene NR3C2, GR gene NR3C1 and genes of GR chaperone molecules FK506 binding protein 5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27549215
DOI: 10.1007/s00406-016-0722-5

Genes

CRHR1
FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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