Article
Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2006
van West Dirk, Van Den Eede Filip, Del-Favero Jurgen, Souery Daniel, Norrback Karl-Fredrik, Van Duijn Cornelia, Sluijs Sam, Adolfsson Rolf, Mendlewicz Julien, Deboutte Dirk, Van Broeckhoven Christine, Claes Stephan
Abstract excerpt
Dysregulation of the hypothalamic-pituitary-adrenal axis, one of the stress-response systems, is one of the key neurobiological features of major depression (MDD). Data supporting the notion that glucocorticoid-mediated feedback inhibition is impaired in MDD come from a multitude of studies demonstrating nonsuppression of cortisol secretion following administration of the synthetic glucocorticoid dexamethasone....
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