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Article

Glucocorticoid receptor gene (NR3C1) promoter is hypermethylated in Thai females with major depressive disorder.

Genetics and molecular research : GMR - 29 Dec 2015

Nantharat M, Wanitchanon T, Amesbutr M, Tammachote R, Praphanphoj V

Abstract excerpt

Major depressive disorder (MDD) has been associated with the stress response in the brain, which is controlled by the hypothalamic-pituitary-adrenal (HPA) axis. This HPA negative feedback mechanism acts via the activation of glucocorticoid receptor, which is encoded by the NR3C1 gene. The methylation status at the promoter of NR3C1 has been correlated with traumatic experiences in early life, which develop into...

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Identifiers

PMID: 26782558
DOI: 10.4238/2015.December.29.15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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