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Article

FKBP5 polymorphism is associated with major depression but not with bipolar disorder.

Journal of affective disorders - 1 Aug 2014

Szczepankiewicz Aleksandra, Leszczyńska-Rodziewicz Anna, Pawlak Joanna, Narozna Beata, Rajewska-Rager Aleksandra, Wilkosc Monika, Zaremba Dorota, Maciukiewicz Malgorzata, Twarowska-Hauser Joanna

Abstract excerpt

BACKGROUND: Altered activity of hypothalamus-pituitary-adrenal glands (HPA) axis in response to stress underlies the pathogenesis of mood disorders such as depression and bipolar disorder. Chaperone proteins regulate sensitivity of glucocorticoid receptor (GR) to steroids. We hypothesized that genetic variants within the FKBP5 - gene encoding co-chaperone protein essential in GR signaling - may influence the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24856550
DOI: 10.1016/j.jad.2014.04.002

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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