Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2009

Kumsta Robert, Moser Dirk, Streit Fabian, Koper Jan Willem, Meyer Jobst, Wüst Stefan

Abstract excerpt

Hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis has been associated with the etiology of major depression. One of the factors underlying altered glucocorticoid signaling might be variability of the glucocorticoid receptor gene (GR, NR3C1). GR polymorphisms have been associated with variability in glucocorticoid sensitivity and endocrine responses to psychosocial stress. Furthermore, a common GR SNP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenocorticotropic Hormone
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Hydrocortisone

Share to Linkage Disequilibrium

Share to Receptors, Glucocorticoid

Share to Stress, Psychological

Share to Transfection

Source

Identifiers

PMID: 18663733
DOI: 10.1002/ajmg.b.30837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance.PMID 18663733Read ↗

Glucocorticoid receptor gene haplotype predicts increased risk of hospital admission for depressive disorders in the Helsinki birth cohort study.Semantic proximity Read ↗

Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression.Semantic proximity Read ↗

Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD).Semantic proximity Read ↗

Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder.Semantic proximity Read ↗

Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics.Semantic proximity Read ↗

Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants.Semantic proximity Read ↗

Unipolar depression and hippocampal volume: impact of DNA sequence variants of the glucocorticoid receptor gene.Semantic proximity Read ↗

The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men.Semantic proximity Read ↗

High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders.Semantic proximity Read ↗

Polymorphisms of the glucocorticoid receptor gene and major depression.Semantic proximity Read ↗

Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease.Semantic proximity Read ↗

Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.