Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of the glucocorticoid receptor gene and major depression.

Biological psychiatry - 15 Apr 2006

van Rossum Elisabeth F C, Binder Elisabeth B, Majer Matthias, Koper Jan W, Ising Marcus, Modell Sieglinde, Salyakina Daria, Lamberts Steven W J, Holsboer Florian

Abstract excerpt

BACKGROUND: The most consistent biological finding in patients with depression is a hyperactivity of the hypothalamic-pituitary-adrenal (HPA)-axis, which might be caused by impaired glucocorticoid signaling. Glucocorticoids act through the glucocorticoid receptor (GR) for which several polymorphisms have been described. The N363S and BclI polymorphisms have been associated with hypersensitivity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Receptors, Glucocorticoid
Share to Antidepressive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asparagine

Share to Corticotropin-Releasing Hormone

Share to Depressive Disorder, Major

Share to Dexamethasone

Share to Hydrocortisone

Share to Serine

Source

Identifiers

PMID: 16580345
DOI: 10.1016/j.biopsych.2006.02.007

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of the glucocorticoid receptor gene and major depression.PMID 16580345Read ↗

Glucocorticoid Receptor Polymorphisms in Major DepressionSemantic proximity Read ↗

Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder.Semantic proximity Read ↗

Glucocorticoid receptor gene polymorphisms in premenopausal women with major depression.Semantic proximity Read ↗

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance.Semantic proximity Read ↗

Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.Semantic proximity Read ↗

Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphismsSemantic proximity Read ↗

Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression.Semantic proximity Read ↗

The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men.Semantic proximity Read ↗

Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience.Semantic proximity Read ↗

Glucocorticoid Receptor Genetic Variants and Response to Fluoxetine in Major Depressive Disorder.Semantic proximity Read ↗

[No association of glucocorticoid receptor gene polymorphism (rs6190) with unipolar and bipolar disorder].Semantic proximity Read ↗

Association between genetic variants and depression in a Romanian cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.