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Article

The Non-Linear Child: Ontogeny, Isoniazid Concentration, and NAT2 Genotype Modulate Enzyme Reaction Kinetics and Metabolism.

EBioMedicine - 1 Sept 2016

Rogers Zoe, Hiruy Hiwot, Pasipanodya Jotam G, Mbowane Chris, Adamson John, Ngotho Lihle, Karim Farina, Jeena Prakash, Bishai William, Gumbo Tawanda

Abstract excerpt

N-acetyltransferase 2 (NAT2) catalyzes the acetylation of isoniazid to N-acetylisoniazid. NAT2 polymorphism explains 88% of isoniazid clearance variability in adults. We examined the effects of clinical and genetic factors on Michaelis-Menten reaction kinetic constants of maximum velocity (Vmax) and affinity (Km) in children 0-10years old. We measured the rates of isoniazid elimination and N-acetylisoniazid...

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Source

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Identifiers

PMID: 27528266
DOI: 10.1016/j.ebiom.2016.07.031
PMCID: PMC5049930

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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