Pharmacogenomics and mutation informatics: correlation of NAT2 mutations and isoniazid acetylation rate.

doi:10.1016/j.drudis.2025.104561

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Article

Pharmacogenomics and mutation informatics: correlation of NAT2 mutations and isoniazid acetylation rate.

Drug discovery today - 1 Jan 2026

Verma Saroj, Patil Vaishali M, Agarwal Uma

Abstract excerpt

Tuberculosis (TB) drug resistance poses a major global health challenge. The first-line antitubercular prodrug isoniazid (INH) is metabolized by N-acetyltransferase 2 (NAT2) and activated by catalase peroxidase (KatG) to inhibit enoyl-acyl carrier protein reductase (InhA) in the mycolic acid biosynthesis pathway. Genetic variations in NAT2 are associated with the formation of slow and fast acetylators,...

Topics

Arylamine N-Acetyltransferase
Isoniazid
Humans
Antitubercular Agents
Acetylation
Mutation
Pharmacogenetics
Tuberculosis
Artificial Intelligence
Animals
Machine Learning

Source

Open in PubMed

Identifiers

PMID: 41314532
DOI: 10.1016/j.drudis.2025.104561

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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