Article
Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers.
Antimicrobial agents and chemotherapy - 1 Nov 2015
Seng Kok-Yong, Hee Kim-Hor, Soon Gaik-Hong, Chew Nicholas, Khoo Saye H, Lee Lawrence Soon-U
Abstract excerpt
In this study, we aimed to quantify the effects of the N-acetyltransferase 2 (NAT2) phenotype on isoniazid (INH) metabolism in vivo and identify other sources of pharmacokinetic variability following single-dose administration in healthy Asian adults. The concentrations of INH and its metabolites acetylisoniazid (AcINH) and isonicotinic acid (INA) in plasma were evaluated in 33 healthy Asians who were also given...
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