Article
Influence of NAT2 Genotype and Maturation on Isoniazid Exposure in Low-Birth-Weight and Preterm Infants With or Without Human Immunodeficiency Virus (HIV) Exposure.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 29 Sept 2022
Béranger Agathe, Bekker Adrie, Solans Belén P, Cotton Mark F, Mirochnick Mark, Violari Avy, Wang Jiajia, Cababasay Mae, Wiesner Lubbe, Browning Renee, Moye Jack, Capparelli Edmund V, Savic Radojka M
Abstract excerpt
BACKGROUND: Isoniazid (INH) metabolism depends on the N-acetyl transferase 2 (NAT2) enzyme, whose maturation process remains unknown in low birth weight (LBW) and preterm infants. We aimed to assess INH exposure and safety in infants receiving oral tuberculosis prevention. METHODS: This population pharmacokinetics (PK) analysis used INH and N-acetyl-isoniazid (ACL) concentrations in infants (BW ≤ 4 kg), including...
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