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Article

Ontogeny of Phase I Metabolism of Drugs

1 Sept 2019

Abstract excerpt

Capturing ontogeny of enzymes involved in phase I metabolism is crucial to improve prediction of dose-concentration and concentration-effect relationships throughout infancy and childhood. Once captured, these patterns can be integrated in semiphysiologically or physiology-based pharmacokinetic models to support predictions in specific pediatric settings or to support pediatric drug development. Although these...

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PMID: 31502685
DOI: 10.1002/jcph.1483

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