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Article

Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine children under isoniazid treatment.

International journal of clinical pharmacology and therapeutics - 1 Apr 2014

Keller Guillermo Alberto, Fabian Lucas, Gomez Matías, Gonzalez Claudio Daniel, Diez Roberto Alejandro, Di Girolamo Guillermo

Abstract excerpt

INTRODUCTION: Metabolic clearance of isoniazid (INH) may be up to 10 times faster in individuals who are rapid acetylators compared with slow acetylators. In addition, the acetylation phenotype has been suggested to change with age. A better knowledge of the age distribution of the acetylation genotype and phenotype in children requiring INH for tuberculosis treatment or prevention could be important to optimize...

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Source

Identifiers

PMID: 24447650
DOI: 10.5414/CP201957

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine children under isoniazid treatment.PMID 24447650Read ↗

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