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Article

The pharmacogenetics of NAT2 enzyme maturation in perinatally HIV exposed infants receiving isoniazid.

Journal of clinical pharmacology - 1 Apr 2012

Zhu Rui, Kiser Jennifer J, Seifart Heiner I, Werely Cedric J, Mitchell Charles D, D'Argenio David Z, Fletcher Courtney V

Abstract excerpt

The roles of the NAT2 genotype and enzyme maturation on isoniazid pharmacokinetics were investigated in South African infants with perinatal HIV exposure enrolled in a randomized, double-blind, controlled trial of isoniazid for prevention of tuberculosis disease and latent infection. Plasma concentration-time measurements of isoniazid from 151 infants (starting at 3-4 months of age) receiving isoniazid 10 to 20...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infectious Disease Transmission, Vertical

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Source

Open in PubMed Open full text

Identifiers

PMID: 21558457
DOI: 10.1177/0091270011402826
PMCID: PMC3182303

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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