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Article

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation

7 Jun 2016

Abstract excerpt

MYC is a key driver of cellular transformation and is deregulated in most human cancers. Studies of MYC and its interactors have provided mechanistic insight into its role as a regulator of gene transcription. MYC has been previously linked to chromatin regulation through its interaction with INI1 (SMARCB1/hSNF5/BAF47), a core member of the SWI/SNF chromatin remodeling complex. INI1 is a potent tumor suppressor...

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PMID: 27267444
DOI: 10.1080/15384101.2016.1146836

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