Article
SMARCB1 Deficiency Integrates Epigenetic Signals to Oncogenic Gene Expression Program Maintenance in Human Acute Myeloid Leukemia
26 Feb 2018
Abstract excerpt
Abstract SWI/SNF is an evolutionarily conserved multi-subunit chromatin remodeling complex that regulates epigenetic architecture and cellular identity. Although SWI/SNF genes are altered in approximately 25% of human malignancies, evidences showing their involvement in tumor cell–autonomous chromatin regulation and transcriptional plasticity are limiting. This study demonstrates that human primary acute myeloid...