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Article

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function.

Nature genetics - 1 May 1999

Cheng S W, Davies K P, Yung E, Beltran R J, Yu J, Kalpana G V

Abstract excerpt

Chromatin organization plays a key role in the regulation of gene expression. The evolutionarily conserved SWI/SNF complex is one of several multiprotein complexes that activate transcription by remodelling chromatin in an ATP-dependent manner. SWI2/SNF2 is an ATPase whose homologues, BRG1 and hB...

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Source

Identifiers

PMID: 10319872
DOI: 10.1038/8811

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10319872-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function.PMID 10319872Read ↗

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformationSemantic proximity Read ↗

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.Semantic proximity Read ↗

A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle.Semantic proximity Read ↗

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SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.Semantic proximity Read ↗

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.Semantic proximity Read ↗

Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer.Semantic proximity Read ↗

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling ComplexSemantic proximity Read ↗

SWI/SNF: a chromatin-remodelling complex with a role in carcinogenesis.Semantic proximity Read ↗

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