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Article

Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex.

Epigenetics & chromatin - 23 Apr 2025

Hao Fengxiang, Zhang Ying, Hou Jiayi, Zhao Bin

Abstract excerpt

The SWI/SNF complex was first identified in yeast and named after studies of mutants critical for the mating-type switch (SWI) and sucrose non-fermenting (SNF) pathways.The SWI/SNF complex plays a pivotal role in regulating gene expression by altering chromatin structure to promote or suppress the expression of specific genes, maintain stem cell pluripotency, and participate in various biological processes....

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Source

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Identifiers

PMID: 40269969
DOI: 10.1186/s13072-025-00590-w
PMCID: PMC12016160

Genes

ARID1A
ARID1B
PBRM1
SMARCA2
SMARCA4
SMARCB1

Provenance

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