Article
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation.
Nature genetics - 1 Feb 2017
Wang Xiaofeng, Lee Ryan S, Alver Burak H, Haswell Jeffrey R, Wang Su, Mieczkowski Jakub, Drier Yotam, Gillespie Shawn M, Archer Tenley C, Wu Jennifer N, Tzvetkov Evgeni P, Troisi Emma C, Pomeroy Scott L, Biegel Jaclyn A, Tolstorukov Michael Y, Bernstein Bradley E, Park Peter J, Roberts Charles W M
Abstract excerpt
SMARCB1 (also known as SNF5, INI1, and BAF47), a core subunit of the SWI/SNF (BAF) chromatin-remodeling complex, is inactivated in nearly all pediatric rhabdoid tumors. These aggressive cancers are among the most genomically stable, suggesting an epigenetic mechanism by which SMARCB1 loss drives transformation. Here we show that, despite having indistinguishable mutational landscapes, human rhabdoid tumors...
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