Article
Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2014
Wang Xiaofeng, Haswell Jeffrey R, Roberts Charles W M
Abstract excerpt
SWI/SNF chromatin remodeling complexes are pleomorphic multisubunit cellular machines that utilize the energy of ATP hydrolysis to modulate chromatin structure. The complexes interact with transcription factors at promoters and enhancers to modulate gene expression and contribute to lineage speci...
Topics
- Animals
- Antineoplastic Agents
- Chromosomal Proteins, Non-Histone
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Humans
- Molecular Targeted Therapy
- Mutation
- Neoplasms
- Protein Subunits
- Signal Transduction