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Article

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.

Structure (London, England : 1993) - 7 Jul 2015

Allen Mark D, Freund Stefan M V, Zinzalla Giovanna, Bycroft Mark

Abstract excerpt

SWI/SNF complexes use the energy of ATP hydrolysis to remodel chromatin. In mammals they play a central role in regulating gene expression during differentiation and proliferation. Mutations in SWI/SNF subunits are among the most frequent gene alterations in cancer. The INI1/hSNF5/SMARCB1 subunit...

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Source

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Identifiers

PMID: 26073604
DOI: 10.1016/j.str.2015.04.021
PMCID: PMC4509781

Genes

PHF10
SKI
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26073604-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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