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Article

Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors

15 May 2012

Abstract excerpt

Emerging evidence demonstrates that subunits of the SWI/SNF chromatin remodeling complex are specifically mutated at high frequency in a variety of human cancer types. SNF5 (SMARCB1/INI1/BAF47), a core subunit of the SWI/SNF complex, is inactivated in the vast majority of rhabdoid tumors (RT), an aggressive type of pediatric cancer. SNF5-deficient cancers are diploid and genomically stable, suggesting that...

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PMID: 22544318
DOI: 10.4161/cc.20280

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Related research

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Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumorsPMID 22544318Read ↗

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