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Article

Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.

Cancer genetics - 1 Sept 2014

Kim Kimberly H, Roberts Charles W M

Abstract excerpt

SMARCB1 (INI1/SNF5/BAF47), a core subunit of the SWI/SNF (BAF) chromatin-remodeling complex, is inactivated in the large majority of rhabdoid tumors, and germline heterozygous SMARCB1 mutations form the basis for rhabdoid predisposition syndrome. Mouse models validated Smarcb1 as a bona fide tumor suppressor, as Smarcb1 inactivation in mice results in 100% of the animals rapidly developing cancer. SMARCB1 was the...

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Source

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Identifiers

PMID: 24853101
DOI: 10.1016/j.cancergen.2014.04.004
PMCID: PMC4195815

Genes

SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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