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Article

SWI/SNF chromatin remodeling complexes and cancer.

American journal of medical genetics. Part C, Seminars in medical genetics - 1 Sept 2014

Biegel Jaclyn A, Busse Tracy M, Weissman Bernard E

Abstract excerpt

The identification of mutations and deletions in the SMARCB1 locus in chromosome band 22q11.2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the SWI/SNF chromatin remodeling complex in cancer. Over the last 15 years, alterations in more than 20 members of the complex have been reported in a variety of human tumors. These include germline mutations and copy number alterations in...

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Source

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Identifiers

PMID: 25169151
DOI: 10.1002/ajmg.c.31410
PMCID: PMC4516040

Genes

SMARCB1
PBRM1
SMARCA4
SMARCE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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