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Article

Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities.

Current opinion in genetics & development - 1 Feb 2017

St Pierre Roodolph, Kadoch Cigall

Abstract excerpt

Mammalian SWI/SNF (BAF) chromatin remodeling complexes orchestrate a diverse set of chromatin alterations which impact transcriptional output. Recent whole-exome sequencing efforts have revealed that the genes encoding subunits of mSWI/SNF complexes are mutated in over 20% of cancers, spanning a wide range of tissue types. The majority of mutations result in loss of subunit protein expression, implicating...

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Identifiers

PMID: 28391084
DOI: 10.1016/j.gde.2017.02.004
PMCID: PMC5777332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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