Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities.

doi:10.1016/j.gde.2017.02.004

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Article

Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities.

Current opinion in genetics & development - 1 Feb 2017

St Pierre Roodolph, Kadoch Cigall

Abstract excerpt

Mammalian SWI/SNF (BAF) chromatin remodeling complexes orchestrate a diverse set of chromatin alterations which impact transcriptional output. Recent whole-exome sequencing efforts have revealed that the genes encoding subunits of mSWI/SNF complexes are mutated in over 20% of cancers, spanning a...

Topics

Animals
Chromosomal Proteins, Non-Histone
Humans
Mammals
Mutation
Neoplasms
Transcription Factors

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