Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma.

Oncotarget - 2 Aug 2016

Zhou Jun, Wen Qiang, Li Sai-Fei, Zhang Yun-Fei, Gao Na, Tian Xin, Fang Yan, Gao Jie, Cui Ming-Zhu, He Xiao-Pei, Jia Lin-Jing, Jin Han, Qiao Hai-Ling

Abstract excerpt

The lack of information concerning individual variation in drug-metabolizing enzymes is one of the most important obstacles for designing personalized medicine approaches for hepatocellular carcinoma (HCC) patients. To assess cytochrome P450 (CYP) in the metabolism of endogenous and exogenous molecules in an HCC setting, the activity changes of 10 major CYPs in microsomes from 105 normal and 102 HCC liver tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Cytochrome P-450 CYP2E1

Share to Cytochrome P-450 CYP3A

Share to Cytochrome P-450 Enzyme System

Share to Fibrosis

Share to Liver Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27203676
DOI: 10.18632/oncotarget.9437
PMCID: PMC5226607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma.PMID 27203676Read ↗

Gene polymorphisms and contents of cytochrome P450s have only limited effects on metabolic activities in human liver microsomes.Semantic proximity Read ↗

Physiological Content and Intrinsic Activities of 10 Cytochrome P450 Isoforms in Human Normal Liver Microsomes.Semantic proximity Read ↗

Polymorphism of CYP450 and cancer susceptibility.Semantic proximity Read ↗

Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.Semantic proximity Read ↗

Cytochrome P450 in Cancer Susceptibility and Treatment.Semantic proximity Read ↗

Distribution Characteristics and Impacting Factors of Drug CYP Enzymes and Transporters in the Gastrointestinal Tract of Chinese Healthy Subjects.Semantic proximity Read ↗

From Genotype to Phenotype: Content and Activities of Cytochromes P450 2A6 in Human Liver In Vitro and Predicted In Vivo.Semantic proximity Read ↗

The frequencies of mutated alleles of CYP2D6 gene in a Turkish population.Semantic proximity Read ↗

Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population.Semantic proximity Read ↗

Substrate-dependent functional alterations of seven CYP2C9 variants found in Japanese subjects.Semantic proximity Read ↗

Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.Semantic proximity Read ↗

CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.