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Article

Gene polymorphisms and contents of cytochrome P450s have only limited effects on metabolic activities in human liver microsomes.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 20 Sept 2016

Gao Na, Tian Xin, Fang Yan, Zhou Jun, Zhang Haifeng, Wen Qiang, Jia Linjing, Gao Jie, Sun Bao, Wei Jingyao, Zhang Yunfei, Cui Mingzhu, Qiao Hailing

Abstract excerpt

Extensive inter-individual variations in pharmacokinetics are considered as a major reason for unpredictable drug responses. As the most important drug metabolic enzymes, inter-individual variations of cytochrome P450 (CYP) activities are not clear in human liver. In this paper, metabolic activities, gene polymorphisms and protein contents of 10 CYPs were determined in 105 human normal liver microsomes. The...

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Identifiers

PMID: 27339126
DOI: 10.1016/j.ejps.2016.06.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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