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Article

Substrate-dependent functional alterations of seven CYP2C9 variants found in Japanese subjects.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2009

Maekawa Keiko, Harakawa Noriko, Sugiyama Emiko, Tohkin Masahiro, Kim Su-Ryang, Kaniwa Nahoko, Katori Noriko, Hasegawa Ryuichi, Yasuda Kazuki, Kamide Kei, Miyata Toshiyuki, Saito Yoshiro, Sawada Jun-ichi

Abstract excerpt

CYP2C9 is a polymorphic enzyme that metabolizes a number of clinically important drugs. In this study, catalytic activities of seven alleles found in Japanese individuals, CYP2C9*3 (I359L), *13 (L90P), *26 (T130R), *28 (Q214L), *30 (A477T), *33 (R132Q), and *34 (R335Q), were assessed using three substrates (diclofenac, losartan, and glimepiride). When expressed in a baculovirus-insect cell system, the holo and...

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PMID: 19541829
DOI: 10.1124/dmd.109.027003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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